Discussion 2CB - drug that boosts dopamine, serotonin and norepinephrine

[LittleJem]

Erm so I have realised 2CB might be very helpful for my depression. It's a psychedelic drug in the same family as MDMA but seemingly safer and MDMA sadly has only worked for me once out of maybe ten times using it.

It boosts brain chemicals and lasts for several hours. I have tried it in pink cocaine recently but not by itself so am going to try it by itself ASAP.

I wish I could get Adderall!! But this might be worth a try…

 

[JoysoftheEmptiness]

Never heard of it, but will look it up.
Its an illegal class a drug in the UK. Just checked out - https://www.talktofrank.com/drug/2c.

 

[LittleJem]

Never heard of it, but will look it up.
Its an illegal class a drug in the UK. Just checked out - https://www.talktofrank.com/drug/2c.

Talk to Frank is quite a preachy drug website and not as informative as other sites. I recommend reading the Wikipedia article on 2CB which is informative and even handed:

2C-B - Wikipedia

en.m.wikipedia.org

And then this article is one of the good ones and there are some useful videos on YouTube too:

2C-B: If LSD and MDMA had a baby

Alexander Shulgin, best known for introducing MDMA to the psychological community, also created over 230 novel psychoactive compounds and documented their effects in the book PiHKAL: A Chemical Love Story written with his wife Ann Shulgin. Among the 200+ compounds discussed was a unique molecule...

psychedelichealth.co.uk

Illegal - I know that bothers some people but the side effects I have got from legal medications are worse. The side effects from 2CB are not that well researched but seem to be more negligible.

For me, illegal means harder to source but am lucky I can source this…I wish everyone could have access to psychedelics with health information and safe use included.

I wish I could also source decent benzos for occasional relief ( my psych refuses this as he wants me tortured). And I wish I could source Adderall as I will never be prescribed it, but for some people it sorts out their depression right away.

Mental illness/trauma and drug use are often good friends. When doctors judge me for it (with no understanding of drugs and no training in them) they just don't have my suffering and they don't understand the need for having a break or (in my dreams) psychedelic healing.

When I mentioned pink cocaine to my psych he said 'rainbow cocaine, blue cocaine' but neither of those things exist. He literally knows hardly anything about drugs and yet he prescribes drugs to drug users. Typical ignorant, arrogant psychiatrist.

I know from all the medications and drugs I've tried that my brain is wonky and chemically out of whack. Anything that helps it feel better is good with me.

YMMV.

Best wishes to all, J

 

[pilotviolin]

hey im glad you found something that works, for me its dxm it just makes me hopeful and keeps me afloat and is the most accessible thing i can manage and be responsible with atm. i havent researched much on 2cb as psychedelics aren't my interest at the moment (it likely will in the future though rn ive been researching some other kinds of plants and substances) but i had a look at some papers and im going to read more as i see it being mentioned a bit and i like pharmacology.

nowhere near benzos, but ive been using chamomile and its a mild but noticable sedative and makes me feel mildly gooey but i vape it, it supposedly works on gaba a little bit. i want to try other similar plants. no idea on the long term but ive been using it for weed withdrawals and it helps take the edge off a little bit and makes drifting off to sleep nice. it has a long half life of about 90hrs but it doesnt feel like it lasts long or is that noticable/impairing. i have a bit less background anxiety though.

 

[LittleJem]

Never heard of it, but will look it up.
Its an illegal class a drug in the UK. Just checked out - https://www.talktofrank.com/drug/2c.

I take it back: Frank info is good.

I have no clue about the long- term side effects and risks of 2CB. Maybe it's worth risking for me.

 

[TheNatureOfDying]

hey im glad you found something that works, for me its dxm it just makes me hopeful and keeps me afloat and is the most accessible thing i can manage and be responsible with atm. i havent researched much on 2cb as psychedelics aren't my interest at the moment (it likely will in the future though rn ive been researching some other kinds of plants and substances) but i had a look at some papers and im going to read more as i see it being mentioned a bit and i like pharmacology.

nowhere near benzos, but ive been using chamomile and its a mild but noticable sedative and makes me feel mildly gooey but i vape it, it supposedly works on gaba a little bit. i want to try other similar plants. no idea on the long term but ive been using it for weed withdrawals and it helps take the edge off a little bit and makes drifting off to sleep nice. it has a long half life of about 90hrs but it doesnt feel like it lasts long or is that noticable/impairing. i have a bit less background anxiety though.

with regards to dxm, i used it a lot over this past year and i felt like it did make me feel less depressed a lot of the time. it was nice to just listen to music and trip for a bit without having to worry about stuff, and i would usually feel pretty alright the next day if not a little out of it. i have been trying to use it less lately, including a six month period where i didn't use it at all.

i'd like to try 2c-b sometime as i am generally interested in psychedelics and have enjoyed using them in the past. i had a friend who tried 2c-b and she really enjoyed it and said it was a pretty energetic high.

i don't really have decent access to substances atm so i'll have to postpone my experimentation for now.

 

[cantthinkofusername]

2cb is okay but its nothing like mdma in my opinion
mdma is 100x more

 

[LittleJem]

2cb is okay but its nothing like mdma in my opinion
mdma is 100x more

Mdma doesn't work on me, sadly.

I said that to a psychiatrist once and he said the cause was 'maybe bad drugs' but I am pretty sure it's my brain being bad. It worked on me once out of maybe eight tries.

 

[todienomore]

Consider a san pedro cactus (mescaline) microdose. Easy extraction. Cycle it though, bad for heart iirc.

i love drugs but getting high is not sustainable. Your body shift gears to compensate (downregulation, upregulation), excess neurotransmitters are neurotoxic. Mdma, adderall, all that shit is burning away receptors unfortunately. And yes you can burn away a ton before there are "clinical" symptoms. Downregulation can last months or years. This is a big issue with alcohol and amphetamine for example.


there are no silver bullets unfortunately

 

[LittleJem]

Just took 25 mg.

Burning receptors - quietipane did that for me this year definitely. Since Q, cocaine is not the same for me.

Pink cocaine working less well too and the last time I had any was a week or two ago.

Aargh no relief at all.

 

[LittleJem]

Fuck well I took a second pill as the first wasn't doing anything. The second has hardly done anything.

My bf has taken one pill and it's working on him.

Am getting to the point where neither legal nor illegal works on me.

with regards to dxm, i used it a lot over this past year and i felt like it did make me feel less depressed a lot of the time. it was nice to just listen to music and trip for a bit without having to worry about stuff, and i would usually feel pretty alright the next day if not a little out of it. i have been trying to use it less lately, including a six month period where i didn't use it at all.

i'd like to try 2c-b sometime as i am generally interested in psychedelics and have enjoyed using them in the past. i had a friend who tried 2c-b and she really enjoyed it and said it was a pretty energetic high.

i don't really have decent access to substances atm so i'll have to postpone my experimentation for now.

How long does DXM last for and how much did you take?

 

[Demi-Fiend]

Every drug has its honeymoon period of bringing the utmost joy. Unfortunately, the effects are short lived. Just like someone mentioned, no silver bullets or golden substance for alleviating everything.

I'm glad to hear 2-B worked for you, regardless!

 

[ms_beaverhousen]

DXM + Wellbutrin = Auvelity for depression
(I do the DIY version.)

Spravato/Ketamine similar MDMA mechanism on neuroplasticity. Wish everyone could try this...

All stimulants and generics are NOT created equal... Finally settled on Vyvanse after trying a fair few. Wish everyone could try a stimulant as I think it's highly underrated for severe depression (as well as benzos).

Haven't been able to try calming drinks so, Idk if it was the chamomile or l-theanine, but this NeuroBliss was interesting to drink years ago.

 

[EvisceratedJester]

Fuck well I took a second pill as the first wasn't doing anything. The second has hardly done anything.

My bf has taken one pill and it's working on him.

Am getting to the point where neither legal nor illegal works on me.

Have you made sure to wait at least 2 weeks? You took both LSD and an SSRI a few days ago and that's probably going to impact how other effective psychedelics are, including 2C-B. You should have waited at least two weeks after you had taken the LSD and SSRI to give your brain time to "reset". I'd say to just try again after two weeks from now and see if that helps.

 

[LunarLight]

2-CB never worked for me, just like MDMA.

 

[LittleJem]

2-CB never worked for me, just like MDMA.

yep, me neither. Does nothing for me. Was hoping!

 

[Ashu]

Talk to Frank is quite a preachy drug website and not as informative as other sites. I recommend reading the Wikipedia article on 2CB which is informative and even handed:

2C-B - Wikipedia

en.m.wikipedia.org

And then this article is one of the good ones and there are some useful videos on YouTube too:

2C-B: If LSD and MDMA had a baby

Alexander Shulgin, best known for introducing MDMA to the psychological community, also created over 230 novel psychoactive compounds and documented their effects in the book PiHKAL: A Chemical Love Story written with his wife Ann Shulgin. Among the 200+ compounds discussed was a unique molecule...

psychedelichealth.co.uk

Illegal - I know that bothers some people but the side effects I have got from legal medications are worse. The side effects from 2CB are not that well researched but seem to be more negligible.

For me, illegal means harder to source but am lucky I can source this…I wish everyone could have access to psychedelics with health information and safe use included.

I wish I could also source decent benzos for occasional relief ( my psych refuses this as he wants me tortured). And I wish I could source Adderall as I will never be prescribed it, but for some people it sorts out their depression right away.

Mental illness/trauma and drug use are often good friends. When doctors judge me for it (with no understanding of drugs and no training in them) they just don't have my suffering and they don't understand the need for having a break or (in my dreams) psychedelic healing.

When I mentioned pink cocaine to my psych he said 'rainbow cocaine, blue cocaine' but neither of those things exist. He literally knows hardly anything about drugs and yet he prescribes drugs to drug users. Typical ignorant, arrogant psychiatrist.

I know from all the medications and drugs I've tried that my brain is wonky and chemically out of whack. Anything that helps it feel better is good with me.

YMMV.

Best wishes to all, J

Yes, psychiatrists don't know us at all, and they never even wanted to. They come for the status and money. Technocrat scum.

 

[LunarLight]

yep, me neither. Does nothing for me. Was hoping!

I've always wondered if this is a matter of serotonin production. But psychiatrists stare at me with giant, clueless, judgmental eyes when I ask them about it.

 

[LittleJem]

When I mentioned pink cocaine to my psychiatrist he said 'blue cocaine, rainbow cocaine'

They are proud of their pig ignorance