There was a fatal case here a while back, though sadly that wasn't the intended effect & his misses ended up getting in trouble.
You see the fella in question had a bit of a drink issue, but at the time had some stomach issues stopping him from drinking, so some wisearse, either him or his misses thought i know lets try an alcohol enemia, said route of administration was used & guess what your butt has shed loads of bloodvessles to absorb the stuff & it handily avoids the livers 'first past the post' filtering, all of which equaled one dead husband & one wife arrested.
And you don't even need anti emetics......