I think, therefore I am.
That sentence describes the only thing you can know for certain. In the context of reality, how can you prove your not in a simulation? How can you prove that your not in the matrix? How can you prove you weren't created 5 seconds ago, and that your memories were fabricated with it?
The point is: Name one thing that you know, beyond a shadow of a doubt, absolutely must be a fact.
And the answer is: The only thing you can know for certain is that you are thinking this thought right now, and as such, you must exist. That you are real. Oh sure, you might be in a simulation, you might be in the matrix, you might have been created 5 seconds ago, but the point still stand. Regardless of how you view the world, politically, figuratively or literally, you exist. Beyond that, nothing can be known for certain.