Plato'sCaveDweller
Sleep is good, death is better.
- Sep 2, 2024
- 513
I've been cooking up my SN plan while I wait to get paid so I can purchase Meto and Propranolol. But I'd like some feedback on my plan just to double check if it's all good. Plus I am unsure of the P dosage, usage, and effects which I'll explain below.
Here's my SN plan:
Fast for 12 or so hours (last meal finished before 12am the night before)
10:00 Cease consumption of water for 2 hours before SN (drinking water to swallow meds though)
10:30 1hr 30m before, take 40mg (40mg X1) of Propranolol
11:00 1hr before take 975mg (325mg X3) of Tylenol
11:20 40 minutes before, take stat dose of 30mg (10mg X3) Metoclopramide and another 40mg of Propranolol
Sometime after taking Meto and P, mix 2 glasses with 50ml of water and 25g of SN each, then wait remaining time
12:00 after roughly ~40 minutes, drink SN
Does the timing of all of this look good? Would you change anything? Additional question, after vomiting (which is likely to happen), should I immediately take my backup glass? or should I wait a short while to give my stomach a brief respite?
As for Propranolol, I have several questions:
First off, I read in a medical journal study that was testing P dosages for POTS sufferers that peak concentrations in the blood stream occur at ~90 minutes after ingestion, with onset effects beginning at ~60 minutes after ingestion (though I've read elsewhere that the onset effects begin at 30 minutes, so I'm not sure). The low effective dose in the study was 20mg, so I'm quadrupling it for myself since I'm dealing with SN here and that can make your heart go bonkers. I know the old dosage suggested by the PPH and forum members used to be anywhere from 400mg to 620mg, but this is an extremely high dose and apparently this is inadvisable due to risk of atrial fibrillation, heart arrhythmia, and other unforeseen side effects. Additionally, if one fails with SN and they've taken a high dosage of P, they can have permanent heart issues. And for heart rate reduction, a therapeutic dose for anxiety is enough (10-30mg) for a measurable reduction in heart rate, and higher and higher doses possibly have diminishing returns with increased side effects and risks. So a lower dosage is better it seems, and as such I think 80mg is probably my best bet, as opposed to several hundred mg. Besides, I'm not trying to completely eliminate tachycardia. I just don't want to endure potentially 200 fucking beats per minute till I pass out, so if I can get that down to something like 120-140, I'm cool with that. When I had a lung collapse, my heart rate almost reached 190 at one point and generally hovered between the 170's and the 180's (same trigger mechanism as SN: substantially reduced oxygen saturation, triggering the brain to increase heart rate to compensate). It was so uncomfortable and disconcerting. A lot of people say tachycardia is nothing to worry about and won't add any distress, but absolutely not in my case. I do not want to experience that again. So I'd like to avoid that in my final moments since SN has more than enough discomforting effects. While Propranolol is now seen as a luxury item, it's almost a necessity for me.
My questions here are:
Is 80mg total a good dose in your opinion? Should I up it a bit to to get my desired heart rate range? Or is 80mg too high for a first time dose (never took the med before)? It's higher than a therapeutic dose (since we're talking about SN here and I'll definitely need something a bit stronger than that), but it's lower than some of the dosages other members have used years ago which ranged from 120-320mg (and going further back, as previously stated, 400-620mg!).
How about the timing of ingestion? A user here on SS reported peak effects of Propranolol at around 47 minutes, while medical studies show the effects kick in fully at around 60-90 minutes, so I'm not sure here. This is why I've spaced out the dose, taking 40mg 90min prior so it for sure reaches peak concentration by the time I take my SN, and another 40mg 40 min before SN that should begin taking some additional effect by then; in theory, the concentration will continue to increase while I'm enduring the symptoms of SN, so it may help as I'm going through it. Does this sounds like a good plan? Anyone have any additional information about the effective timing of this drug?
Is it alright taking the second Propran at the same time as the Meto? I've researched both drugs, and they have no interactions. But will taking these two drugs at the same time inhibit their abilities to saturate my blood stream quick enough? They'll have about 40 minutes to enter the bloodstream and concentrate.
Anyone taking Propranolol for a medical issue that could offer some insight into dosage and subsequent effects? Any words of advice?
Anyone else using P in their SN plan have any feedback here? What's your dosage and timing for P and the reasoning behind it?
Sorry if this is too many questions, but I'm trying to be as thorough as possible (dotting my Is, crossing my Ts). Answer what you can if you have any helpful info, if not it's no biggie.
Here's my SN plan:
Fast for 12 or so hours (last meal finished before 12am the night before)
10:00 Cease consumption of water for 2 hours before SN (drinking water to swallow meds though)
10:30 1hr 30m before, take 40mg (40mg X1) of Propranolol
11:00 1hr before take 975mg (325mg X3) of Tylenol
11:20 40 minutes before, take stat dose of 30mg (10mg X3) Metoclopramide and another 40mg of Propranolol
Sometime after taking Meto and P, mix 2 glasses with 50ml of water and 25g of SN each, then wait remaining time
12:00 after roughly ~40 minutes, drink SN
Does the timing of all of this look good? Would you change anything? Additional question, after vomiting (which is likely to happen), should I immediately take my backup glass? or should I wait a short while to give my stomach a brief respite?
As for Propranolol, I have several questions:
First off, I read in a medical journal study that was testing P dosages for POTS sufferers that peak concentrations in the blood stream occur at ~90 minutes after ingestion, with onset effects beginning at ~60 minutes after ingestion (though I've read elsewhere that the onset effects begin at 30 minutes, so I'm not sure). The low effective dose in the study was 20mg, so I'm quadrupling it for myself since I'm dealing with SN here and that can make your heart go bonkers. I know the old dosage suggested by the PPH and forum members used to be anywhere from 400mg to 620mg, but this is an extremely high dose and apparently this is inadvisable due to risk of atrial fibrillation, heart arrhythmia, and other unforeseen side effects. Additionally, if one fails with SN and they've taken a high dosage of P, they can have permanent heart issues. And for heart rate reduction, a therapeutic dose for anxiety is enough (10-30mg) for a measurable reduction in heart rate, and higher and higher doses possibly have diminishing returns with increased side effects and risks. So a lower dosage is better it seems, and as such I think 80mg is probably my best bet, as opposed to several hundred mg. Besides, I'm not trying to completely eliminate tachycardia. I just don't want to endure potentially 200 fucking beats per minute till I pass out, so if I can get that down to something like 120-140, I'm cool with that. When I had a lung collapse, my heart rate almost reached 190 at one point and generally hovered between the 170's and the 180's (same trigger mechanism as SN: substantially reduced oxygen saturation, triggering the brain to increase heart rate to compensate). It was so uncomfortable and disconcerting. A lot of people say tachycardia is nothing to worry about and won't add any distress, but absolutely not in my case. I do not want to experience that again. So I'd like to avoid that in my final moments since SN has more than enough discomforting effects. While Propranolol is now seen as a luxury item, it's almost a necessity for me.
My questions here are:
Is 80mg total a good dose in your opinion? Should I up it a bit to to get my desired heart rate range? Or is 80mg too high for a first time dose (never took the med before)? It's higher than a therapeutic dose (since we're talking about SN here and I'll definitely need something a bit stronger than that), but it's lower than some of the dosages other members have used years ago which ranged from 120-320mg (and going further back, as previously stated, 400-620mg!).
How about the timing of ingestion? A user here on SS reported peak effects of Propranolol at around 47 minutes, while medical studies show the effects kick in fully at around 60-90 minutes, so I'm not sure here. This is why I've spaced out the dose, taking 40mg 90min prior so it for sure reaches peak concentration by the time I take my SN, and another 40mg 40 min before SN that should begin taking some additional effect by then; in theory, the concentration will continue to increase while I'm enduring the symptoms of SN, so it may help as I'm going through it. Does this sounds like a good plan? Anyone have any additional information about the effective timing of this drug?
Is it alright taking the second Propran at the same time as the Meto? I've researched both drugs, and they have no interactions. But will taking these two drugs at the same time inhibit their abilities to saturate my blood stream quick enough? They'll have about 40 minutes to enter the bloodstream and concentrate.
Anyone taking Propranolol for a medical issue that could offer some insight into dosage and subsequent effects? Any words of advice?
Anyone else using P in their SN plan have any feedback here? What's your dosage and timing for P and the reasoning behind it?
Sorry if this is too many questions, but I'm trying to be as thorough as possible (dotting my Is, crossing my Ts). Answer what you can if you have any helpful info, if not it's no biggie.
