Yeah, this why a car is harder to use than, say, a tent. Aren't your vents the same portals where the heat/ac flow from? How you generating CO? Idk, back in the "old" days, when people were able to use their car exhaust and just ran an extension hose from the tailpipe into the car's cabin, I doubt they did any sealing at all. Seal the vents, maybe under the doors. You may have CO escape into the trunk behind the back seat. If you want to get "crazy", block off the front from the back, effectively making a smaller "space". I think a better "safeguard" is to use way more charcoal than you think necessary, that will produce CO at a greater rate than any loss that may occur. Ofc, you need a "safe" place to place it all, too (fire hazzard) - another issue with vehicles.