Help How to test Antiemetic for SN use

[FadingSnowFake]

I was wondering how to test to see if an antiemetic will work (I'm using ondansetron). I mean should we try to "simulate" the experience by fasting and taking something which may make us nauseous? I took a tablet this morning and drank water with a bit of table salt, but it seems like a pointless exercise. How do we know if something may or may not work for us?

Apologies if it's a stupid question.

 

[unluckysadness]

Good question. I'm waiting for my meto and I hope they won't send me a fake med (I've ordered it online)

 

[Zardoz]

I was wondering how to test to see if an antiemetic will work (I'm using ondansetron). I mean should we try to "simulate" the experience by fasting and taking something which may make us nauseous? I took a tablet this morning and drank water with a bit of table salt, but it seems like a pointless exercise. How do we know if something may or may not work for us?

Apologies if it's a stupid question.

It's not a stupid question. One I've been concerned with as well.
I don't have a definitive answer. I guess if there is something that is known to make you nauseous and potentially vomit, then that would be a good test. Perhaps a food you can't stand?
Otherwise the main concern would be having an adverse reaction to the drug itself, especially as the protocol recommends taking a very high dose.
I'm intending to use both Ondansetron and Meto together (the PPH has this for the 5-drug mix), about half the separate protocol dose of both. I've taken one tab of each to test but not yet together and not in the full high dose. I don't know whether to test run the full protocol dose beforehand or not. I felt a bit shaky and edgy on the Meto, and I've read a few reports of people saying they didn't get on with it. The Ondansetron seemed fine. Perhaps it was just my own anxiety.
What are your plans, if any, to test the AE's any further?

 

[DOHARDTHINGS24]

I don't know if you can really test on whether it will stop you vomiting. And you may vomit anyway. I think the point is to trial it to make sure you don't get nasty side effects & to do a meds interaction checker as well. Also, my AE isn't meto, but the side effects are rare at the start & become more likely over time. So maybe separate your trials from when you're planning, consider stat dose if concerned, & prepare for the fact you may vomit anyway.
I'm not sure if that's useful, but it's all I've got, sorry, best of luck.

 

[FadingSnowFake]

It's not a stupid question. One I've been concerned with as well.
I don't have a definitive answer. I guess if there is something that is known to make you nauseous and potentially vomit, then that would be a good test. Perhaps a food you can't stand?
Otherwise the main concern would be having an adverse reaction to the drug itself, especially as the protocol recommends taking a very high dose.
I'm intending to use both Ondansetron and Meto together (the PPH has this for the 5-drug mix), about half the separate protocol dose of both. I've taken one tab of each to test but not yet together and not in the full high dose. I don't know whether to test run the full protocol dose beforehand or not. I felt a bit shaky and edgy on the Meto, and I've read a few reports of people saying they didn't get on with it. The Ondansetron seemed fine. Perhaps it was just my own anxiety.
What are your plans, if any, to test the AE's any further?

Thanks, I think we can never know for sure how we will react on the day, and I agree that anxiety will also have an influence. Maybe I'll get more tablets to test, then take the dose I would want to (or half) and see if there are adverse effects that could get in the way of proceeding with SN. But I'm not sure and wouldn't want to confuse the body too much before. I suspect we would feel some effect because it was designed to counter nausea from chemo. I'm sure I will vomit anyways though, as long as I'm able to keep enough SN in.

I don't know if you can really test on whether it will stop you vomiting. And you may vomit anyway. I think the point is to trial it to make sure you don't get nasty side effects & to do a meds interaction checker as well. Also, my AE isn't meto, but the side effects are rare at the start & become more likely over time. So maybe separate your trials from when you're planning, consider stat dose if concerned, & prepare for the fact you may vomit anyway.
I'm not sure if that's useful, but it's all I've got, sorry, best of luck.

Thanks, this is useful. How far would you suggest separating the trial from planned date? I'm planning on the stat dose anyways. best of luck to you too.

 

[DOHARDTHINGS24]

Thanks, I think we can never know for sure how we will react on the day, and I agree that anxiety will also have an influence. Maybe I'll get more tablets to test, then take the dose I would want to (or half) and see if there are adverse effects that could get in the way of proceeding with SN. But I'm not sure and wouldn't want to confuse the body too much before. I suspect we would feel some effect because it was designed to counter nausea from chemo. I'm sure I will vomit anyways though, as long as I'm able to keep enough SN in.

Thanks, this is useful. How far would you suggest separating the trial from planned date? I'm planning on the stat dose anyways. best of luck to you too.

I'm no expert, sorry. And not taking meto. But the worst of the potential side effects of mine (prochlor-something, can't spell) were extra-pyramidal or something, especially interacting with my current meds (plus also sedation & confusion). I read up but forgot most. I think it talked a lot about uncontrollable movements & jerkiness, that sort of thing. And desire to move - I remember something about shaking your hands, maybe?? To trick your brain into thinking you were moving.
But mostly, that if you're not taking meds that interact, the side effects were mostly after weeks of use.
I think a trial is safest. And online meds checker if other meds. I was red for meto so couldn't get legitimately, but only orange for mine, so managed a prescription for that. I've done 2 trials for the jerkiness stuff, I have no idea about the sedation, I did both trials when I was sick with other illness, because it was the only times I could trial a drug in the day.
I think if you're doing stat, you probably only need a gap day in between. A guess.
I do not recommend this, at all, but I downed a shot of salt water (apparently dangerous), & not on a day when I trialled AE, & even with that I had rolling waves of nausea & walked around saying "why me?" I'm not kidding. It was pretty funny. I have a lot of illness in my life, too much, but not much nausea. I can withstand pain to extraordinary levels according to every intensive care I've been in, who always say I rate pain as a 5 when others say 10 - but when it comes to vomiting, I'm a toddler that cries A LOT, that just wants their mummy. It's pathetic. I wish I could swap the nausea for pain, I imagine I'm the minority there.
Apologies for ramble - adhd & tbi.
That's all the info I can think of & I'm out of time.
I received some extraordinary help here today, so I just wanted to be useful to someone else, but that's all I can do, sorry, best of luck.

 

[Zardoz]

Thanks, I think we can never know for sure how we will react on the day, and I agree that anxiety will also have an influence. Maybe I'll get more tablets to test, then take the dose I would want to (or half) and see if there are adverse effects that could get in the way of proceeding with SN. But I'm not sure and wouldn't want to confuse the body too much before. I suspect we would feel some effect because it was designed to counter nausea from chemo. I'm sure I will vomit anyways though, as long as I'm able to keep enough SN in.

Thanks, this is useful. How far would you suggest separating the trial from planned date? I'm planning on the stat dose anyways. best of luck to you too.

I don't think it matters. You don't want the test dose still in your system though, so a few days minimum I would think to let it clear out. Longer is better I would think. I'm no expert, that's just a hunch, and so obviously don't take that as medical fact. The main thing is to make sure you can tolerate it and not have any serious side effects (especially extrapyramidal). But we'd only know this for sure from taking the high protocol STAT dose. These AE's are only meant to be taken for a short time, like a few days, not for long term use. I think this is because the risk of long term side effects can increase? The meto (which you are not using?) made me drowsy. I fell asleep (I'd had a few beers as well) which is potentially useful but I'm concerned that a high dose will knock me out too early, which is why I'm also using the Ondansetron alongside it as well.

 

[cowboypants]

It doesn't matter people still vomit even with Antiemetics. SN is different from normal salt as well and the dosage, taste. While i can't go deep as I haven't tasted ofc.

Ondansetron has less side effect than meto, but still don't see much use in testing it as long it's a reputed product. I do wish I could simulate like you said to see if there's any leak in my protocol. You will be facing worse stuff with SN than from AE