Opioid Megathread & Overview

[JoysoftheEmptiness]

Thank you for taking the time for writing at such length.

The only reason I added Mirtazapine was because I kept seeing on various post including this particular drug.

Much appreciated.

I overdosed on Mirtazapine, didn't manage to CTB, but I was really ill after that. Dislike overdosing on anything now.

 

[sg95]

I have acquired about a gram of Fentynal and am looking to use this as my method.
My question is what method is best. I would prefer oral ingestion but concerned about vomiting it up. Then, IV. (...nasal sounds horrible)

I have 2 concerns:
- Oral: What is the onset in to unconciousness?
- IV: How much could I feasibly fit in a single insulin needle?

 

[sleepforever81]

How much tramadol is the fatal dose.

 

[Rhizomorph1]

I have acquired about a gram of Fentynal and am looking to use this as my method.
My question is what method is best. I would prefer oral ingestion but concerned about vomiting it up. Then, IV. (...nasal sounds horrible)

I have 2 concerns:
- Oral: What is the onset in to unconciousness?
- IV: How much could I feasibly fit in a single insulin needle?

Aqueous solubility of fentanyl = approximately 1,300mg/mL according to this information sheet.

So, if your insulin syringe contains 1mL of water (preferably distilled water), you can put up to 1.3 grams of 100% pure fentanyl in it. If you have a larger syringe (e.g., 3mL syringe), you just multiply the 1,000 figure by the number of mL (e.g., 3x1,300 = 3,900mg or 3.9 grams).

However, it's incredibly unlikely your fentanyl is 100% pure. I used to do drug checking analysis with a spectrometer and only saw samples above 30% concentration on one or two occasions.

The average concentration in the illicit drug supply is around 15% so you likely have about 150mg (give or take) in your whole 1 gram sample. The only way to know for sure is to test it using a spectrometer at a drug checking/harm reduction location.

Also, I have no idea what the solubility of the other cutting agents and buffs (usually some citric acid & an inert sugar like mannitol) are, which means you could risk clogging up your syringe with massive amounts of substance. This is unlikely but may be added reason to get a syringe with a larger-than-necessary volume (3-10mL would be suitable)

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The oral onset will take between 20 minutes to a 2 hours depending on your metabolism, how much you've eaten, etc. following the SN protocol is the best bet, simply replacing the SN with your opioid. However, opioids are notorious nauseants meaning the risk of vomiting and CTB failure with oral administration is astronomically higher, even with an antiemetic. This is why I can *NOT* recommend oral consumption in good faith; the bioavailability is already far lower than other routes, and the risk of injury and ctb failure is high.

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[/HR

The other reliable administration option (but still unreliable method overall for the reasons discussed in the OP) is rectal administration using an oral syringe inserted about 1-2 knuckles length past the rectum; if anyone reading has a needle phobia, has trouble finding a vein, etc.

How much tramadol is the fatal dose.

I'm uncertain but I would highly recommend against using tramadol as the serotonergic activity is bound to cause adverse side effects, and it almost unanimously comes in pill form which is almost impossible to inject; read the comment above for issues regarding vomiting.

I would be highly surprised if someone successfully ctb with tramadol or other weak opioids (e.g., codeine).

The risk of injury without successful ctb is high, especially given the added serotonin activity (serotonin syndrome; non-fatal seizures, vomiting, tremors, hallucinations, agitation, neuromuscular pain, etc.)

 

[Ugory]

Rhizomorph1

Hi
You recommend rectal ROA. But 1 gr of methadone doesn't dissolve in 1 ml of water..

 

[Rhizomorph1]

Rhizomorph1

Hi
You recommend rectal ROA. But 1 gr of methadone doesn't dissolve in 1 ml of water..

Methadone has quite a long half life and attenuated peak blood concentration. Although it's a strong opioid it's specific pharmacokinetics makes it quite challenging to OD on compared to heroin, fentanyl, or oxy.

Just for consideration; I don't recommend it.

For rectal ROA you can use plenty more than 1ml. Use however much necessary to dissolve your drug (I still don't recommend opioids, however; this info is only if you decide to do it despite the moderate reliability)

 

[justwannaleave]

Do you think snorting a high amount of heroin could lead to death? It's the easiest ROA for me.

 

[finishLana]

What are the risks if opioid is placed in an acid resistant enteric capsules, bypassing the stomach and released in the small intestine

 

[k1w1]

How much tramadol is the fatal dose.

Nothing....it is rubbish

 

[Rhizomorph1]

IDo you think snorting a high amount of heroin could lead to death? It's the easiest ROA for me.

It could. It could not.

The reliability is moderate so your chances of success are in the same ballpark as your chances of failure.

IV or rectal administration will always absorb quicker and more of the drug than snorting. A lot get clogged in the sinuses especially at high doses. I don't think insufflation is a very effective ROA for ctb.

 

[ThatRussianDude]

If I may ask a question, I take methadone daily around 170mg for a few years now. And I also want to catch the bus. So if I take like a gram of methadone + loads of benzos + 500ml of vodka, would I be able to catch the bus?

 

[Romanticize]

If I may ask a question, I take methadone daily around 170mg for a few years now. And I also want to catch the bus. So if I take like a gram of methadone + loads of benzos + 500ml of vodka, would I be able to catch the bus?

probably yes.
im taking big doses of oxy and morph daily for 6 years now
its like 600-1200mg morph daily (oral, crushed pills).
I used to IV 400-600mg, but the only vein i had, collapsed.
I dont feel anything even after doing 1.2g of morph. My tolerance is huge.


I also plan to ctb using morph, ingesting like 3-4g of morphine, 100mg of clonaz, and maybe adding SN.
Without SN i think the plan is likely to fail, given route (oral), my tolerance, and shit load of tablets i will need to swallow (its 4000/200 = 20 morphine and 100/2=50 clon, 70 tablets total. (vomiting, slow absorption).

What do you think OP?

 

[ThatRussianDude]

probably yes.
im taking big doses of oxy and morph daily for 6 years now
its like 600-1200mg morph daily (oral, crushed pills).
I used to IV 400-600mg, but the only vein i had, collapsed.
I dont feel anything even after doing 1.2g of morph. My tolerance is huge.


I also plan

probably yes.
im taking big doses of oxy and morph daily for 6 years now
its like 600-1200mg morph daily (oral, crushed pills).
I used to IV 400-600mg, but the only vein i had, collapsed.
I dont feel anything even after doing 1.2g of morph. My tolerance is huge.


I also plan to ctb using morph, ingesting like 3-4g of morphine, 100mg of clonaz, and maybe adding SN.
Without SN i think the plan is likely to fail, given route (oral), my tolerance, and shit load of tablets i will need to swallow (its 4000/200 = 20 morphine and 100/2=50 clon, 70 tablets total. (vomiting, slow absorption).

What do you think OP?

In your case, if I was living in the EU, I would go on the dark web and get methadone/fentanyl+benzos+alcohol. Since your tolerance is only for mórphine, methadone/fentanyl will send you flying far far away. The old style holding a bag over your face until you doze out will make it 100% You might also need consider your femoral vein. It is not that hard to hit.

 

[Romanticize]

I had methadone thru a friend, drank like 100 or 150ml (of stronger version, 5% not 2%) - i felt nothing.
tolerance for opioids is a cross tolerance, so oxy/morph also affect fent.
Although i agree, F is stronger and more effective in delivering resp depression.
I dont want to go to darkweb, dont want to search for other veins as well. I'd rather add SN to morphine / clonazepam mix, bc those are the substances which are available to me at the moment.
I know that SN is mentally hard and challenging, so I want my opio and benzo to dull the anxiety, and SN to deliver the final blow.

 

[Lawliet]

thank you for this. i wish there was more information on butrans/belbuca/buprenorphine as it's the second strongest opiate outside of fentanyl. it's 40 times stronger than morphine. it's primarily prescribed to people with chronic pain. issue is, it's distributed mostly in micrograms. i've done transdermal patches and sublingual films.

i can't use ibuprofen or basic pain killers for SN because they don't affect me.

 

[sleepforever81]

Nothing about aspirin, it severely toxic in high amounts.

 

[Peter Skellern]

thank you for this. i wish there was more information on butrans/belbuca/buprenorphine as it's the second strongest opiate outside of fentanyl. it's 40 times stronger than morphine. it's primarily prescribed to people with chronic pain. issue is, it's distributed mostly in micrograms. i've done transdermal patches and sublingual films.

i can't use ibuprofen or basic pain killers for SN because they don't affect me.

Whats the fatal dose re Buprenorphine?

 

[Peter Skellern]

If you are opioid naive (0 tolerance) and add some vodka shots, odds are very high you will CTB. Of course, you need to crush the pills into fine powder, not swallow them as a whole [they are controlled release]

Aren't you just likely to be sick (vomit) and it to fail? Opioids are notorious for that even with an antiemetic.

 

[Rhizomorph1]

Aren't you just likely to be sick (vomit) and it to fail? Opioids are notorious for that even with an antiemetic.

This.

 

[Eudaimonic]

What are your thoughts on this? https://i.sanctioned-suicide.net/images/2022/03/147490_Oxycodon__Fentanyl_guide_English.pdf

 

[legoshi]

I know it said no RC but if the RC are allegedly way higher than fent and heroin wouldn't they in theory work?

 

[Rhizomorph1]

I know it said no RC but if the RC are allegedly way higher than fent and heroin wouldn't they in theory work?

In theory.

In theory they could also have a whole range of adverse effects, genetic variances in metabolism or absorption contributing to unreliability, etc.

I wouldn't rely on it personally; I'd prefer to be confident in my method which involves accounting for variables; RCs leaves those variates unknown.

 

[legoshi]

In theory.

In theory they could also have a whole range of adverse effects, genetic variances in metabolism or absorption contributing to unreliability, etc.

I wouldn't rely on it personally; I'd prefer to be confident in my method which involves accounting for variables; RCs leaves those variates unknown.

What if you took like a whole gram or two?

 

[Rhizomorph1]

What if you took like a whole gram or two?

This will increase effectiveness but the main issue is that you are likely to vomit, even with an antiemetic. Even with preferable routes like IV or per rectal, it will be challenging to absorb the dose fast enough. Significant amounts can be metabolized quite quickly by some users with higher genetic tolerance (more enzymes, differences in cardiovascular processes like bloodflow, absorption in fatty tissues, antioxidants which break down the active substance, and carrier proteins/ligands which can carry the drug away from active binding sites in the brain). Also, syringes can only dissolve so much substance, meaning a lot may get clogged up or simply not end up in the bloodstream.

As I mentioned in the OP, 2 grams are likely to still only contain a few milligrams of active substance due to either cuts in street derived product or pill fillers from pharmeceuticals so the actual dose will be far smaller than it appears at face value.

I still retain the fact that opioids will never be more than low to moderately reliable even with these fail-safes/good practices.

SN is always a better choice.

 

[Solace]

What are the risks if opioid is placed in an acid resistant enteric capsules, bypassing the stomach and released in the small intestine

I would also be interested in an answer to this question

 

[legoshi]

This will increase effectiveness but the main issue is that you are likely to vomit, even with an antiemetic. Even with preferable routes like IV or per rectal, it will be challenging to absorb the dose fast enough. Significant amounts can be metabolized quite quickly by some users with higher genetic tolerance (more enzymes, differences in cardiovascular processes like bloodflow, absorption in fatty tissues, antioxidants which break down the active substance, and carrier proteins/ligands which can carry the drug away from active binding sites in the brain). Also, syringes can only dissolve so much substance, meaning a lot may get clogged up or simply not end up in the bloodstream.

As I mentioned in the OP, 2 grams are likely to still only contain a few milligrams of active substance due to either cuts in street derived product or pill fillers from pharmeceuticals so the actual dose will be far smaller than it appears at face value.

I still retain the fact that opioids will never be more than low to moderately reliable even with these fail-safes/good practices.

SN is always a better choice.

What about fent? It's supposedly out here wiping out everyone

 

[RadiantNumber]

I wish I could obtain and use it, but this is strictly controled in my country