Method Proposing a new, easily-accessible method - Propofol (A Theoretical Method of Dying - The Two Drug Combination - Emulating BC's MAiD Protocol)

[justwannadip]

ok I found the syringe and the needle. Are you for sure that this will work if you inject it into a vein in your arm? Like you said I should not pass out within 10seconds right? And what happens to me if I do? Will i risk being a vegetable or brain damage or something like that?

And what is up with this part?

"In fact, arm-brain circulation time is required to reach the effect site. This is not less than 10 seconds. If necessary, negative inotropic can be used to reduce cardiac output before injection."

Can you explain the arm-brain circulation time thing and what is negative iontropic and why is that used to reduce cardia output before injection?

also is there a way i can inject something inside myself first, such as like saline, to know that I've hit the vein? like...I just want to make sure the needle is in whenever I do the injection. I don't want to waste this stuff. How would i test to make sure that the needle is inside of the vein? So theoretically I could have one syringe connected to the needle with saline and then unscrew that syringe and attach another syringe to the needle with anestofol and then inject it?

and please tell me what happens if i pass out before the 10seconds, am i screwed?

As much as I want a peaceful exit where I pass out quick, this just seems too complex. I feel like there's many possibilities of things going wrong. Even injecting an iv needle on yourself with no training is not a trivial task. If you manage to attempt or create a system that works, pls share as I'd also be interested in it. Out of curiosity, why not try the less complex methods that are already out there like SN or CO/N gas?

 

[Csmith8827]

SN is trashy and it's not fast enough. I don't know much about gas. I just wish this guy would hurry up and get back to me. I'm trying to do this as soon as i can.

 

[justwannadip]

SN is trashy and it's not fast enough. I don't know much about gas. I just wish this guy would hurry up and get back to me. I'm trying to do this as soon as i can.

I would say inert gas methods are much simpler and the materials are much easier to access. Charcoal (CO) method is probably the easiest, and nitrogen second. I wouldn't bank on methods that haven't been readily tried and tested. There's megathreads on inert gas on the resource section.

 

[maniac116]

I think this is a winner!
I actually believe propofol alone would work (ie Michael Jackson).
Any barbiturate has the potential to be very effective

 

[J&L383]

Full IV line bit tricky although in combination with profonol & then potassium would definitely do the job, but setting up a robust IV line is a bitch, especially keeping it in place.

This is the problem, most people don't have this kind of expertise . The exit bag setup is much easier in comparison. And easier to source materials.

 

[endofline2010]

ok I found the syringe and the needle. Are you for sure that this will work if you inject it into a vein in your arm? Like you said I should not pass out within 10seconds right? And what happens to me if I do? Will i risk being a vegetable or brain damage or something like that?

And what is up with this part?

"In fact, arm-brain circulation time is required to reach the effect site. This is not less than 10 seconds. If necessary, negative inotropic can be used to reduce cardiac output before injection."

Can you explain the arm-brain circulation time thing and what is negative iontropic and why is that used to reduce cardia output before injection?

also is there a way i can inject something inside myself first, such as like saline, to know that I've hit the vein? like...I just want to make sure the needle is in whenever I do the injection. I don't want to waste this stuff. How would i test to make sure that the needle is inside of the vein? So theoretically I could have one syringe connected to the needle with saline and then unscrew that syringe and attach another syringe to the needle with anestofol and then inject it?

and please tell me what happens if i pass out before the 10seconds, am i screwed?

I would do a ton of research before even attempting this. There are much simpler/easier chemical approaches that have verified success rates.

 

[norain]

Propofol doesn't work orally?

 

[Csmith8827]

Bumping this...

 

[Sunset Limited]

ok I found the syringe and the needle. Are you for sure that this will work if you inject it into a vein in your arm? Like you said I should not pass out within 10seconds right? And what happens to me if I do? Will i risk being a vegetable or brain damage or something like that?

And what is up with this part?

"In fact, arm-brain circulation time is required to reach the effect site. This is not less than 10 seconds. If necessary, negative inotropic can be used to reduce cardiac output before injection."

Can you explain the arm-brain circulation time thing and what is negative iontropic and why is that used to reduce cardia output before injection?

also is there a way i can inject something inside myself first, such as like saline, to know that I've hit the vein? like...I just want to make sure the needle is in whenever I do the injection. I don't want to waste this stuff. How would i test to make sure that the needle is inside of the vein? So theoretically I could have one syringe connected to the needle with saline and then unscrew that syringe and attach another syringe to the needle with anestofol and then inject it?

and please tell me what happens if i pass out before the 10seconds, am i screwed?

This method is not realistic without you are a healthcare professional sorry.

Propofol doesn't work orally?

Oral bioavailability of propofol is only 2.7%.

 

[Csmith8827]

This method is not realistic without you are a healthcare professional sorry.

Oral bioavailability of propofol is only 2.7%.

dude just explain it more. And please refrain from using broken english it makes you sound unreliable.

 

[Sunset Limited]

dude just explain it more. And please refrain from using broken english it makes you sound unreliable.

I am using google translate and answered too many questions. You can search about propofol in forum. I can't answer again and again. If you are not healthcare professional propofol is complicated for you.

 

[Sappy Sandpiper]

Dunno about the etiquette on reviving a thread like this but I wanted to ask if anyone knows about the efficacy of propofol after its expiration date? I have a limited amount that expired throughout this past year and am regretting not offing myself earlier. The vials are still pristine, I'm just wondering if Propofol degrades over time? Literature I see online only looks into how long it lasts after it's been drawn up and not how long it's good for while still in the vial.

 

[Gone.]

the only goal of a therapist is to get you to follow the law and have some way of paying them enough money so they can continue their parasitic relationship with you. any improvement that happens during therapy is incidental to the main purpose of extracting resources from clients and getting clients to snitch on themselves so there are more government records of what people are doing.

Oh my therapist is government funded. And she's really helpful and passionate to help me recover.

That drip infusion system sounds really complex. How difficult is it to setup and acquire the necessary instruments? Do you have a system set up?

It's absurdly simple... Just a peripheral iv catheter, IV extension if the catheter doesn't have one built-in, an IV bag, and an IV tubing set.

Ok i found the Anestofol.


where can i buy this syringe/needle combination? I can't find it anywhere online.

You want the IV catheter, not the syringe and needle. Information above~

As much as I want a peaceful exit where I pass out quick, this just seems too complex. I feel like there's many possibilities of things going wrong. Even injecting an iv needle on yourself with no training is not a trivial task. If you manage to attempt or create a system that works, pls share as I'd also be interested in it. Out of curiosity, why not try the less complex methods that are already out there like SN or CO/N gas?

It's not that complex... I learned how to do this as a child. On this, should I make a post on how to put in an IV catheter?

I would do a ton of research before even attempting this. There are much simpler/easier chemical approaches that have verified success rates.

Surprisingly no. There are not many simpler and easier approaches...

This method is not realistic without you are a healthcare professional sorry.

Oral bioavailability of propofol is only 2.7%.

Well, I think all the IV drug users would like to have a word with you haha
And yeah, oral propofol isn't going to do anything.

Dunno about the etiquette on reviving a thread like this but I wanted to ask if anyone knows about the efficacy of propofol after its expiration date? I have a limited amount that expired throughout this past year and am regretting not offing myself earlier. The vials are still pristine, I'm just wondering if Propofol degrades over time? Literature I see online only looks into how long it lasts after it's been drawn up and not how long it's good for while still in the vial.

Eh, expired drugs should still work from experience- Although I wouldn't advise this to a patient of course since it's important to follow expiry dates, but in a pinch they should be fine.

 

[sevennn]

oh wow you are still there. i was just rereading this thread ahah. yes can you post more about the IV process. i think that would be really helpful. thank you for this information you've provided <3 and how have you been?

 

[justwannadip]

Oh my therapist is government funded. And she's really helpful and passionate to help me recover.


It's absurdly simple... Just a peripheral iv catheter, IV extension if the catheter doesn't have one built-in, an IV bag, and an IV tubing set.


You want the IV catheter, not the syringe and needle. Information above~


It's not that complex... I learned how to do this as a child. On this, should I make a post on how to put in an IV catheter?


Surprisingly no. There are not many simpler and easier approaches...


Well, I think all the IV drug users would like to have a word with you haha
And yeah, oral propofol isn't going to do anything.


Eh, expired drugs should still work from experience- Although I wouldn't advise this to a patient of course since it's important to follow expiry dates, but in a pinch they should be fine.

Yes, I think a post on how to put in an iv catheter and all the tools required would be very helpful. Images or videos could help with the explanation as well. I'll be looking forward to that!

 

[Csmith8827]

Oh my therapist is government funded. And she's really helpful and passionate to help me recover.


It's absurdly simple... Just a peripheral iv catheter, IV extension if the catheter doesn't have one built-in, an IV bag, and an IV tubing set.


You want the IV catheter, not the syringe and needle. Information above~


It's not that complex... I learned how to do this as a child. On this, should I make a post on how to put in an IV catheter?


Surprisingly no. There are not many simpler and easier approaches...


Well, I think all the IV drug users would like to have a word with you haha
And yeah, oral propofol isn't going to do anything.


Eh, expired drugs should still work from experience- Although I wouldn't advise this to a patient of course since it's important to follow expiry dates, but in a pinch they should be fine.

Yeah I mean if this is so easy please make a thread telling us how to do it and how it works. Instructions would be nice. I'm interested.

 

[Gone.]

oh wow you are still there. i was just rereading this thread ahah. yes can you post more about the IV process. i think that would be really helpful. thank you for this information you've provided <3 and how have you been?

Yup! Still around. Been doing okay! :) You?

 

[sevennn]

Yup! Still around. Been doing okay! :) You?

i've been better ahah (to put it lightly) thanks for sharing this btw

 

[Sunset Limited]

Well, I think all the IV drug users would like to have a word with you haha

Everyone is not an IV drug user and has not large veins that are easily visible. Placing a catheter and injecting with a needle are two different things and don't forget too many members are here with mental and physically ill. While IV is difficult enough for even a healthy person, for someone with physical or mental illness, managing it under the pressure of SI can become impossible.

There is also rectal thiopental, which is now easier and more realistic way than propofol. It is possible to buy thiopental from Indiamart for everyone. No cannulas, no injectors.

 

[justwannadip]

Everyone is not an IV drug user and has not large veins that are easily visible. Placing a catheter and injecting with a needle are two different things and don't forget too many members are here with mental and physically ill. While IV is difficult enough for even a healthy person, for someone with physical or mental illness, managing it under the pressure of SI can become impossible.

There is also rectal thiopental, which is now easier and more realistic way than propofol. It is possible to buy thiopental from Indiamart for everyone. No cannulas, no injectors.

There hasn't been enough accounts or research showing the efficacy of rectal administration of thiopental

 

[Sunset Limited]

There hasn't been enough accounts or research showing the efficacy of rectal administration of thiopental

We know about thiopental's rectal pharmacokinetics. It is already used in procedural sedation as rectal. Also there is a suicide case report with rectal thio.

https://www.ajnr.org/content/ajnr/16/1/111.full.pdf

My "scape plan" method (boof barbiturate + intranasal opioid)

Well, I have 20 grams of Thiopental bought in India and 500mg of Protonitazepyne (a more potent analogue than fentanyl) on the way. This is my "escape plan" when my world comes crashing down. After much experimentation and study, the plan is to dissolve 10g of thiopental in 10ml of warm water...

sanctioned-suicide.net

 

[attheend13]

I propose a new method based off BC's MAiD process:

Accessible Version
Full details below~

What you need:
1000mg of propofol - You can get this from Russian clearnet pharmacies. It is marketed for the euthanasia for animals. Propofol is generally not a controlled substance, and is widely used for the induction of anesthesia.
10ml of saline for injection - You can get this from your local pharmacy. Just ask.
0.5mg per kg Lidocaine 1% - You can also get this from your local pharmacy. Again, just ask.
IV Catheter (20G) - You can buy this from medical suppliers online.
IV tubing - You can buy this from any medical supply store... Again...
Tegaderm dressing for the IV - Again, purchasable from the pharmacy. Just ask.

Procedure:
Push 10ml of saline to ensure patency of IV catheter
Push lidocaine 0.5mg/kg of 1% preparation to numb the veins as sometimes propofol hurts on injection.
Wait for five minutes.
Administer propofol 1000mg via an IV syringe pump or drip (just stick the end of the iv tubing into the bottle) over 30 seconds — This induces anaesthesia and death. The IV syringe pump or drip is chosen as it will continue the infusion postmortem to ensure sufficient serum concentration.


Full Article
I came by a document titled "Medical Assistance in Dying (MAID) Protocols and Procedures Handbook of the Comox Valley, BC" (Reggler & Daws, 2021) and found interest in this document. It outlines the following protocol for medically assisted suicide by the intravenous route:

1. Saline 10 ml (upon insertion of new cannula or to ensure patency of existing)
2. Midazolam 10-20mg 2-4ml of 5mg/ml preparation
3. Saline 10ml (may be omitted)
4. Lidocaine 40mg 4ml of 1% preparation; pause to allow effect
5. Saline 10ml (may be omitted)
6. Propofol 1000mg 100ml of 10mg/ml preparation; give slowly especially if veins small or patient)
7. Saline 10ml (mandatory; prevents crystallization or Propofol with Rocuronium)
8. Rocuronium 200mg 20ml of 10mg/ml preparation
9. Saline 10ml (mandatory; ensures full dose delivered centrally)

I have decided to investigate the intravenous route as the oral route is extremely uncomfortable and can take up to twelve hours for an individual to die from such ingestion, and a complication rate of up to 14.8%. (pp. 18-19, Worthington, Finlay & Regnard, 2022)
Based on this guideline, I propose the following:

1. Saline 10ml (To ensure patency of IV catheter)
2. The midazolam is excluded as it's primary purpose is to reduce awareness of mild burning sensation, which the lidocaine should be effective at preventing. Ten to seventy percent of patients experience this in the absence of pretreatment. (p. 8, Reggler & Daws, 2021). However, pretreatment with lidocaine at 0.5mg/kg should be sufficient. (Kang et al, 2010)
3. Lidocaine 0.5mg/kg of 1% preparation; (The lidocaine is set to 0.5mg/kg as per Kang et al., 2010)
4. Propofol 1000mg via an IV syringe pump over 30 seconds - This induces anesthesia and death. The IV syringe pump is chosen as it will continue the infusion postmortem to ensure sufficient serum concentration.

Existing case studies suggests the possible use of propofol as a monotherapy in the use of medically asssisted dying, as it's use in physician suicides (primarily anesthesiologists) is widespread. In fact, induction agents are the leading drugs used for suicides among anesthesiologists. (Yentis, Shinde, Plunkett & Mortimore, 2019)

Bibliography:

1. Anna Pia Colucci, Gagliano‐Candela R, Aventaggiato L, et al. Suicide by Self‐Administration of a Drug Mixture (Propofol, Midazolam, and Zolpidem) in an Anesthesiologist: The First Case Report in Italy. Journal of Forensic Sciences. 2013;58(3):837-841. doi:https://doi.org/10.1111/1556-4029.12053

2. Silviya Stoykova, Kiryakova T, Nikolov D, Nedzhib A, Ivayla Pantcheva, Vasil Atanasov. Self-administrated propofol – a case report of a physician suicide. Annales de Toxicologie Analytique. 2018;30(2):142-148. doi:https://doi.org/10.1016/j.toxac.2018.03.002

3. Kirby RR, Colaw JM, Douglas MM. Death from Propofol: Accident, Suicide, or Murder? Anesthesia & Analgesia. 2009;108(4):1182-1184. doi:https://doi.org/10.1213/ane.0b013e318198d45e

4. Reggler J, Daws T. Medical Assistance in Dying (MAID) Protocols and Procedures Handbook Comox Valley, BC 2017.; 2017. https://divisionsbc.ca/sites/default/files/51936/Medical Assistance in Dying (MAID) Protocols and Procedures Handbook Comox Valley 2017 - 2nd edition_0.pdf

5. Yentis, S.M., Shinde, S., Plunkett, E. and Mortimore, A. (2019), Suicide amongst anaesthetists – an Association of Anaesthetists survey. Anaesthesia, 74: 1365-1373. https://doi.org/10.1111/anae.14727

Interesting. I tried to make application to maid but they aren't taking it for depression until 2027 or something. Then you still need so much including two psychiatrists to sign off. How can something be so difficult? I get why they need to carefully set criteria and protect the vulnerable, but for those of us who want relief from unmanageable pain it's just another huge hurdle. Thanks for the info.

 

[Sunset Limited]

Dunno about the etiquette on reviving a thread like this but I wanted to ask if anyone knows about the efficacy of propofol after its expiration date? I have a limited amount that expired throughout this past year and am regretting not offing myself earlier. The vials are still pristine, I'm just wondering if Propofol degrades over time? Literature I see online only looks into how long it lasts after it's been drawn up and not how long it's good for while still in the vial.

If we are talking about propofol, purity is not only problem. Propofol is an oil emulsion. When you put it in a syringe and see oil bubbles that means emulsion is broken. You can't see them in the glass. We don't know what happens if you inject broken emulsion. Main reason of broken emulsions is storing vials above 24 C°.

 

[voldetort785]

You can place an IV line in your foot, and make sure it's a good gauge (20 - 16g). Placing an IV is very different to taking bloods or injecting, so if you are thinking of doing this, you need to practice. If you place it correctly, you can check if it's working using saline flush.

Another alternative would be to check into an A&E department with an excuse that you feel unwell, abdominal pain, have chest palpitations etc - patients often have an IV placed by the triage nurse on admission to A&E. You could then just walk out with it, although depending on the country you live in and it's healthcare system, that may or may not be so easy.

 

[Csmith8827]

You can place an IV line in your foot, and make sure it's a good gauge (20 - 16g). Placing an IV is very different to taking bloods or injecting, so if you are thinking of doing this, you need to practice. If you place it correctly, you can check if it's working using saline flush.

Another alternative would be to check into an A&E department with an excuse that you feel unwell, abdominal pain, have chest palpitations etc - patients often have an IV placed by the triage nurse on admission to A&E. You could then just walk out with it, although depending on the country you live in and it's healthcare system, that may or may not be so easy.

So walk out with the iv in your arm then fill the injector up with anestfol (propofol) then inject it? Correct?

 

[Gone.]

i've been better ahah (to put it lightly) thanks for sharing this btw

Lovely :)

Everyone is not an IV drug user and has not large veins that are easily visible. Placing a catheter and injecting with a needle are two different things and don't forget too many members are here with mental and physically ill. While IV is difficult enough for even a healthy person, for someone with physical or mental illness, managing it under the pressure of SI can become impossible.

There is also rectal thiopental, which is now easier and more realistic way than propofol. It is possible to buy thiopental from Indiamart for everyone. No cannulas, no injectors.

You can also inject with a needle if you have a large enough barrel. I'll take a look at thiopental sodium per rectum.

Interesting. I tried to make application to maid but they aren't taking it for depression until 2027 or something. Then you still need so much including two psychiatrists to sign off. How can something be so difficult? I get why they need to carefully set criteria and protect the vulnerable, but for those of us who want relief from unmanageable pain it's just another huge hurdle. Thanks for the info.

If you're autistic or otherwise "neurodevelopmentally disabled" you can request it with that as the chief "grievous and irremediable medical condition". (?WV v MV, [2024] AJ No 334, 2024 ABKB 174, Legislative Background: Bill C-7 (2021))

If we are talking about propofol, purity is not only problem. Propofol is an oil emulsion. When you put it in a syringe and see oil bubbles that means emulsion is broken. You can't see them in the glass. We don't know what happens if you inject broken emulsion. Main reason of broken emulsions is storing vials above 24 C°.

"Store between 4°C to 25°C (40°F to 77°F); refrigeration is not required. Do not freeze. Shake well before use. Withdraw from vial into a syringe immediately after sterile vented spike inserted. Administration should begin immediately and completed within 12 hours after the vial has been opened. Do not use if there is evidence of excessive creaming or aggregation, large visible droplets, or separation of phases of emulsion" (Lexicomp) so yeah, store between 4C to 25C...

You can place an IV line in your foot, and make sure it's a good gauge (20 - 16g). Placing an IV is very different to taking bloods or injecting, so if you are thinking of doing this, you need to practice. If you place it correctly, you can check if it's working using saline flush.

Another alternative would be to check into an A&E department with an excuse that you feel unwell, abdominal pain, have chest palpitations etc - patients often have an IV placed by the triage nurse on admission to A&E. You could then just walk out with it, although depending on the country you live in and it's healthcare system, that may or may not be so easy.

So walk out with the iv in your arm then fill the injector up with anestfol (propofol) then inject it? Correct?

Oh yeah that could work too :P You'll be surprised how many people do this to shoot up.

 

[voldetort785]

So walk out with the iv in your arm then fill the injector up with anestfol (propofol) then inject it? Correct?

Yes, however, depending on whether you are left or right handed, it may be difficult to attach the tubing - so keep that in mind if you go to A&E, and direct the nurse to place it where suits best (and obviously have some excuse prepared - patients often just have a preference for an IV site or you can say you injured the arm you dont want the iv to be placed in etc

 

[Gone.]

Yes, however, depending on whether you are left or right handed, it may be difficult to attach the tubing - so keep that in mind if you go to A&E, and direct the nurse to place it where suits best (and obviously have some excuse prepared - patients often just have a preference for an IV site or you can say you injured the arm you dont want the iv to be placed in etc

Just say that they'll have an easier time with the veins in the <left/right> arm and they'll look there first for sure haha